"Amines, crucial components in various industries, play a pivotal role in the synthesis of pharmaceuticals, agrochemicals, and specialty chemicals. Recognizing the environmental impact of conventional methods for their preparation, our study centers on the utilization of abundantly available natural molecules, specifically amino acids, as precursors for short chain amine synthesis. This paper focuses on the biocatalyst, L-valine decarboxylase from Streptomyces viridifaciens (VlmD), delving into the substrate scope, catalytic activity, and cost-effective scalability of an enzymatic process for amine synthesis. Additionally, we investigate the feasibility of immobilizing VlmD, aiming to pave the way for its effective use in industrial applications. Our study exploits the SpinChem system and provides a comprehensive understanding of the potential and limitations of this biocatalyst."
Highlights:
- The study demonstrates scalable enzymatic synthesis of short-chain amines using: SpinChem rotating bed reactor system and Immobilized L-valine decarboxylase (VlmD)
- Highlights eco-friendly potential of biocatalysis as alternative to energy-intensive chemical processes
- Proves industrial viability through stable and effective immobilization on alginate beads and enhanced mass transfer in SpinChem's rotating bed reactor
Keywords: #Biocatalysis #AminoAcids #Alginates #SpinChem #Amines