Enzyme Technology Alliance (ETA)

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Last year, SpinChem joined the Enzyme Technology Alliance — a group of six trailblazing European companies, collaborating to bring competitive solutions for protein development processes to market at scale.

Transforming biotech through collaboration

The Enzyme Technology Alliance was established to replace harmful processes with environmentally friendly alternatives, benefiting not just a more sustainable industry but also enabling companies to improve their production profitability. It comprised six small to medium-sized companies, with SpinChem and Allozymes joining the four founding companies: Candidum GmbH, Aminoverse B.V., ChiralVision B.V., and Enzymicals AG.

Representatives of the Enzyme Technology Alliance member companies gathered at CPHI Barcelona, showcasing the collaborative spirit of this innovative biotech partnership

The Alliance's approach signifies a new way of problem-solving in the biotech industry. By offering comprehensive access to protein development processes, it enables global startups and corporations to bring their innovations to market more efficiently.

The collaboration can help accelerate advancements in biotechnology, potentially leading to breakthroughs in fields such as medicine, agriculture, and environmental sustainability and embracing a more cooperative and supportive partnership.

Broad expertise in research, development, and manufacturing is essential for the successful journey from protein sequence to a final biocatalytic process intended for large-scale implementation.

How ETA solves enzyme development challenges

ETA was founded to address the growing need for integrated, sustainable, and scalable enzyme-based solutions in industries like pharmaceuticals, chemicals, and biotechnology. Enzymes offer a greener alternative to traditional chemical processes, but developing them efficiently requires expertise across multiple disciplines.

By combining the strengths of specialized companies, ETA:

Accelerates time-to-market for enzyme innovations.
Reduces complexity in R&D and scale-up.
Offers sustainable alternatives to harmful chemical processes.
Supports circular economy principles by enabling biocatalytic production.

In short, ETA was created to make enzyme development faster, smarter, and more environmentally responsible.

SpinChem's contribution to enzyme optimization

For companies in biotech, pharmaceutical, chemical and other process industries struggling with slow, inefficient enzyme processes and costly scale-up challenges, SpinChem's innovative Rotating Bed Reactor (RBR) technology significantly improves mass transfer and reduces process time. RBR technology helps to eliminate common challenges like enzyme degradation, long reaction times, and poor yields in heterogeneous reactions.

At SpinChem, our commitment is not just technical; it's part of a larger vision to contribute to a more sustainable future. With the Alliance, we can make a difference in the world. Being relatively small companies, we are also flexible and agile, able to adapt and respond quickly to market needs.

SpinChem team member presenting innovative biocatalysis solutions at a conference with rotating bed reactor displayed at the banner

Biotrans 2025

Meet SpinChem at International Symposium on Biocatalysis and Biotransformations

29 Jun 2025 - 03 Jul 2025

Basel, Switzerland

09:00 - 09:00

Enzyme Technology Alliance capabilities from sequence to value

Together, the ETA members offer a seamless integration of services across the enzyme development pipeline

Enzyme Discovery – Utilizing bioinformatics and modeling to identify potential enzymes.
Enzyme Engineering – Applying AI and computational tools for enzyme optimization.
Process Development – Developing and optimizing enzymatic processes for industrial applications.
Process Intensification – Enhancing reaction efficiency and scalability through advanced technologies.
Scale-Up – Transitioning from laboratory-scale processes to full-scale manufacturing.

Current Members of the Enzyme Technology Alliance

Members of Enzyme Technology Alliance — Logos of the members of the Enzyme Technology Alliance

As of October 2024, since Bio-Prodict's joining of the ETA, it comprises the following seven specialized biotech companies:

1. Allozymes, Singapore – Utilizes proprietary microfluidics technology to perform ultra-high-throughput enzyme screening (up to 10 million variants per day). This accelerates the discovery and development of custom enzymes for applications such as active pharmaceutical ingredient (API) production.

2. Aminoverse B.V., The Netherlands – Focuses on early-stage enzyme innovation, combining wet-lab expertise with AI-driven tools like EnzyMAP and EnzyREC. They offer extensive libraries of unspecific peroxygenases and ketoglutarate-dependent oxygenases for rapid screening and development.

3. Bio-Prodict B.V., The Netherlands – Provides AI-powered protein engineering through its 3DM Engineering platform, which streamlines protein design and optimization. Their tools assist in intelligent protein selection, targeted mutations, and iterative optimization, while also offering integrated intellectual property (IP) navigation.

4. Candidum GmbH, Germany – Specializes in computational enzyme design, creating custom enzyme solutions by integrating computational methods to reduce complexity and enhance predictability in enzyme development.

5. ChiralVision B.V., The Netherlands – Offers expertise in enzyme immobilization and process development, facilitating the transition from enzyme discovery to scalable production processes.

6. Enzymicals AG, Germany – Provides services in enzyme production and process development, supporting projects from initial catalyst discovery to full-scale manufacturing, including current Good Manufacturing Practice (cGMP) production of APIs.

7. SpinChem AB – Develops Rotating Bed Reactor (RBR) technology, enhancing chemical reactions by improving efficiency and sustainability. SpinChem's Rotating Bed Reactor technology significantly enhances process intensification and scalability due to its clever concept - the rotating packed bed actively forces liquid through immobilized materials, leading to superior mass transfer rates and more efficient chemical processes compared to traditional reactors.

Find out more about the Alliance here

Frequently asked questions

What is the Enzyme Technology Alliance and what does it do?

The Enzyme Technology Alliance (ETA) is a collaborative group of seven innovative biotech companies that work together to develop and scale up sustainable enzyme solutions. The alliance combines expertise in enzyme discovery, engineering, and process development to help companies bring innovative biotech products to market faster and more efficiently.

Who are the current members of the Enzyme Technology Alliance?

The Enzyme Technology Alliance comprises seven specialized biotech companies: Allozymes (Singapore), Aminoverse B.V. (Netherlands), Bio-Prodict B.V. (Netherlands), Candidum GmbH (Germany), ChiralVision B.V. (Netherlands), Enzymicals AG (Germany), and SpinChem AB (Sweden). Each member brings unique expertise in areas like enzyme screening, AI-driven tools, computational design, and process development.

How can SpinChem's RBR technology improve enzyme processes?

SpinChem's Rotating Bed Reactor (RBR) technology significantly improves enzyme processes by enhancing mass transfer rates and reducing process time. This innovative technology helps solve common challenges in enzyme reactions, including degradation issues, lengthy reaction times, and low yields, making industrial-scale enzyme processes more efficient and cost-effective.

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What are the benefits of working with the Enzyme Technology Alliance?

Working with the Enzyme Technology Alliance provides access to comprehensive enzyme development services, from initial discovery to full-scale production. Companies benefit from combined expertise across multiple disciplines, faster development times, reduced R&D complexity, and sustainable solutions that can improve production profitability.

Willing to know more? Contact us today