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At SpinChem, our passion drives us to create innovative solutions that contribute to cleaner oceans and purer air. We believe that our technology can play a crucial role in addressing some of the most pressing environmental challenges of our time.

Our commitment to sustainability is reflected in our versatile SpinChem® rotating bed reactor, which finds applications across a wide range of industries. From water purification and toxic waste treatment to the production of renewable fuels, cosmetics, and pharmaceuticals, our technology is making a significant impact on both industrial processes and environmental conservation efforts.

By continuously pushing the boundaries of what's possible in synthesis, production, and purification, we strive to create a world where technological advancement goes hand in hand with environmental stewardship. Our goal is not just to innovate, but to innovate responsibly, always keeping in mind the health of our planet and its oceans.

Technology

The SpinChem® Rotating Bed Reactor (RBR) is at the heart of our innovative technology. This versatile device enhances mass transfer in heterogeneous reactions, significantly improving efficiency and productivity in various chemical processes.

Key features of the RBR include:

High mass transfer rates due to forced convection
Flexible design allowing for easy scale-up
Reduced processing times compared to traditional methods
Improved product quality and yield

The RBR's unique design makes it particularly effective in applications such as catalysis, ion exchange, and adsorption, enabling more sustainable and efficient industrial processes across multiple sectors.

The SpinChem® Rotating Bed Reactor (RBR) operates on a simple yet powerful principle:

The reactor consists of a cylindrical rotating chamber.
This core, or "bed," is filled with solid particles such as catalysts, adsorbents, or immobilized enzymes.
As the bed rotates, it creates a centrifugal force that pushes the liquid outwards through the bed.
This forced flow significantly enhances the contact between the liquid and the solid particles.

The result is a dramatic increase in mass transfer rates, leading to faster reactions, more efficient separations, and improved overall process performance. This unique design allows for easy scaling and adaptation to various chemical processes, making it a versatile solution for numerous industrial applications.

Biocatalysis

Biocatalysis refers to the use of natural catalysts, such as enzymes or whole cells, to perform chemical transformations on substrates, often to produce desired products in a more environmentally friendly and efficient manner compared to traditional chemical methods. This approach is widely used in industries like pharmaceuticals, biotechnology, and food processing.

Enzyme Technology Alliance

The Enzyme Technology Alliance (ETA) is a collaborative initiative that brings together leading experts and organizations in the field of enzyme technology. This alliance aims to accelerate innovation, share knowledge, and develop cutting-edge solutions in biocatalysis and enzyme engineering.

Key objectives of the ETA include:

Fostering research and development in enzyme technology
Promoting the adoption of sustainable biocatalytic processes in industry
Facilitating knowledge transfer between academia and industry
Developing standardized methods and best practices in enzyme technology

Through this alliance, we at SpinChem are able to leverage a vast network of expertise, enhancing our capabilities in biocatalysis and expanding the potential applications of our Rotating Bed Reactor technology in enzyme-based processes.

Collaborative Offerings

Together with our partners in the Enzyme Technology Alliance, SpinChem can offer clients a comprehensive suite of services and technologies:

Enzyme Discovery and Engineering: Leveraging the bioinformatics, modeling, and AI-supported enzyme engineering capabilities of partners like Candidum, Aminoverse, and Allozymes.
Biocatalyst Immobilization: Combining SpinChem's expertise in solid phase utilization with ChiralVision's 16 years of experience in designing immobilized enzyme processes.
Process Development and Scale-up: Utilizing SpinChem's rotating bed reactor technology alongside the alliance's collective expertise in DOE-based process intensification and scale-up of enzyme production and chemo-enzymatic processes.
Custom Solutions: Offering tailored solutions for diverse chemistry and API production, supported by the alliance's combined 150 years of experience in managing projects from enzyme discovery to cGMP enzymatic production of APIs.

Mass Transfer

Mass transfer in liquid-solid reactions is a crucial process in chemical engineering, particularly in heterogeneous systems. It involves the movement of molecules or ions from one phase to another, typically from a liquid bulk to a solid surface or vice versa. This transfer is essential for many industrial processes, including adsorption, ion exchange, and heterogeneous catalysis.

The efficiency of mass transfer significantly impacts the overall reaction rate and yield. Factors affecting mass transfer include:

Surface area of the solid phase
Concentration gradients
Fluid dynamics (e.g., mixing and flow patterns)
Physical properties of the liquid and solid phases

Enhancing mass transfer is a key focus in process optimization, as it can lead to faster reactions, improved product quality, and reduced energy consumption. Technologies like SpinChem's Rotating Bed Reactor are designed to address these challenges by creating optimal conditions for efficient mass transfer in liquid-solid systems.

This graph compares the reaction rates (1/s) of two systems: an Anchor Stirrer and a Rotating Bed Reactor, as a function of Revolutions per Minute (RPM). It highlights differences in mass transfer limitations between the two stirring systems.

Key Observations:

1. Reaction Rate Increases with RPM:

For both systems, the reaction rate increases with RPM initially. This indicates improved mixing and mass transfer as the systems operate at higher speeds.

2. Performance of the Anchor Stirrer:

The Anchor Stirrer reaches a plateau in reaction rate around 500 RPM, suggesting that mass transfer limitations dominate beyond this point. Further increasing RPM does not significantly improve the reaction rate.

3. Performance of the Rotating Bed Reactor:

The Rotating Bed Reactor demonstrates a continuous increase in reaction rate across the full RPM range shown. This suggests it is less affected by mass transfer limitations, maintaining efficient mixing and transport at higher speeds.

4. Overall Comparison:

- At lower RPMs (50–200 RPM), the Anchor Stirrer slightly outperforms the Rotating Bed Reactor.

- At higher RPMs (300+ RPM), the Rotating Bed Reactor outperforms the Anchor Stirrer, particularly after the Anchor Stirrer's performance plateaus.

Mass Transfer Implications:

The plateau observed for the Anchor Stirrer reflects mass transfer limitations—possibly due to insufficient turbulence or mixing efficiency at higher speeds.
The Rotating Bed Reactor likely provides superior mass transfer capabilities, maintaining effective transport of reactants to the reaction site even at high speeds.

The video from SpinChem demonstrates a comparative analysis between a Rotating Bed Reactor (RBR) and a Stirred Tank Reactor (STR) in neutralizing a sodium hydroxide solution using a cation exchange resin. The RBR showcases superior performance, achieving faster reaction rates and producing a clear final product without the need for post-process separation.

Key Observations:

Enhanced Mass Transfer: The RBR's design facilitates efficient mass transfer by rotating a packed bed of solid-phase material, such as catalysts or adsorbents, within the reactor. This rotation generates centrifugal forces that drive the liquid through the solid phase at high flow rates, significantly improving the interaction between the liquid and solid phases.
Improved Reaction Speed: In the video, the RBR neutralizes the sodium hydroxide solution more rapidly than the STR. This increased speed is attributed to the RBR's ability to maintain a high relative velocity between the liquid and solid phases, thereby enhancing mass transfer rates.
Elimination of Post-Process Separation: The RBR confines the solid-phase material within a rotating cylinder equipped with filters, preventing solid particles from dispersing into the liquid. As a result, the final product is clear, eliminating the need for additional separation steps post-reaction.

Observed Enzyme Activity of immobilized enzymes in a Rotating Bed Reactor — This bar graph depicts the Observed Enzyme Activity (U/g) of immobilized enzymes in a Rotating Bed Reactor (RBR) at various Revolutions per Minute (RPM) settings.

Key Observations Finding the Right RPM:

1. Trend of Enzyme Activity with RPM:

Enzyme activity increases with RPM up to 300 RPM.

At 400 RPM and 500 RPM, the activity remains constant, indicating no significant further improvement.

2. Optimal RPM:

The optimal RPM for maximum enzyme activity is 300 RPM, as it achieves the highest activity without any additional gain at higher speeds.

3. Insights:

- Below 300 RPM, lower turbulence and mixing likely limit substrate-enzyme interaction, reducing the observed activity.
- Above 300 RPM, the system may reach a mass transfer or mechanical limit where increasing RPM does not enhance enzyme-substrate interactions further.
- Higher RPMs beyond 300-400 may increase energy costs without additional benefits to enzyme activity.

The paper titled "Intrinsic Kinetics Resolution of an Enantioselective Transesterification Catalyzed with the Immobilized Enzyme Novozym435" provides detailed insights into the kinetic performance of the immobilized enzyme system. Among the key findings, the study highlights that a rotational speed of 400 RPM is optimal for balancing effective mass transfer and maintaining enzymatic efficiency.

The authors emphasise that at this RPM, the system achieves an ideal equilibrium between minimizing diffusion limitations and avoiding excess mechanical shear, which could potentially impact the structural integrity of the enzyme or substrate. This verification aligns with experimental evidence and supports the conclusion that 400 RPM offers the best operational efficiency for the studied enzymatic process.

Reference: Chaussard, N., Nikitine, C., & Fongarland, P. (2023). Intrinsic Kinetics Resolution of an Enantioselective Transesterification Catalyzed with the Immobilized Enzyme Novozym435. ACS Engineering, **https://doi.org/10.1021/acsengineeringau.4c00030**.

Enzyme Immobilisation

Enzyme immobilization is a technique that involves attaching enzymes to a solid support or carrier, effectively "fixing" them in place. This process offers several advantages over using free enzymes in solution:

Enhanced stability: Immobilized enzymes often show increased resistance to environmental changes such as temperature and pH.
Improved reusability: The enzymes can be easily separated from the reaction mixture and reused multiple times.
Increased efficiency: In some cases, immobilization can lead to higher catalytic activity and specificity.
Better process control: Immobilized enzymes allow for more controlled and continuous operations in industrial settings.

Common methods of immobilization include adsorption, covalent binding, entrapment, and cross-linking. The choice of method depends on the specific enzyme, the support material, and the intended application. In the context of SpinChem's Rotating Bed Reactor technology, enzyme immobilization plays a crucial role in optimizing biocatalytic processes and enhancing overall system performance.

Alginate Encapsulation

An example of enzyme immobilization is demonstrated in the study titled "Cost-Effective and Scalable Enzyme-Mediated Preparation of Short-Chain Primary Amines". This work explores the use of alginate encapsulation for immobilizing the enzyme L-valine decarboxylase from Streptomyces viridifaciens (VlmD). The immobilized enzyme system is optimized for industrial applications, leveraging its catalytic activity to produce short-chain primary amines. The paper highlights the potential of alginate-based encapsulation as a scalable and cost-effective method for enzyme immobilization, providing yields of various amines such as isobutylamine, isopentylamine, and (R)-1-amino-2-propanol. This approach not only ensures enzyme stability and reusability but also demonstrates the feasibility of scaling up biocatalytic processes in industrial settings.

Reference: Gianolio, S., Rassati, B., & Paradisi, F. (2024). Cost-Effective and Scalable Enzyme-Mediated Preparation of Short-Chain Primary Amines. Helvetica Chimica Acta, https://doi.org/10.1002/hlca.202400078.

In-situ Immobilisation

In-situ immobilization is an efficient approach where enzymes are immobilized directly within the rotating bed reactor, eliminating the need for separate immobilization steps outside the reaction vessel. This method integrates immobilization and catalysis, reducing time and costs while maintaining enzyme stability and activity. An example is the study "Optimization of Enzymatic Transesterification of Acid Oil for Biodiesel Production Using a Low-Cost Lipase", which explores the use of low-cost lipases with different regioselectivities for biodiesel production. The study demonstrates the synergy of enzymes under optimal transesterification conditions, showcasing the potential of in-situ immobilization to enhance industrial enzymatic processes.

Reference: Moschona, A., Spanou, A., Pavlidis, I. V., Karabelas, A. J., & Patsios, S. I. (2024). Optimization of Enzymatic Transesterification of Acid Oil for Biodiesel Production Using a Low-Cost Lipase. Applied Biochemistry and Biotechnology. https://doi.org/10.1007/s12010-024-04941-3.

New Enzyme Carriers

Our partner ChiralVision is at the forefront of developing innovative enzyme carriers that focus on sustainability and efficiency. A notable advancement involves diaminated cellulose beads (DAB), which serve as highly efficient and environmentally friendly supports for industrially relevant lipases. These carriers are created through chemical functionalization, including oxidation and reductive amination processes, ensuring enzyme activity is retained and recyclable over multiple cycles. The DAB technology also offers superior mechanical stability and biodegradability, making it a sustainable alternative to conventional plastic-based carriers. This supports greener biocatalytic processes while maintaining industrial scalability and enzyme reusability.

Reference: ****Calfano, D., Schoevaart, R., Barnard, K. E., et al. (2024). Diaminated Cellulose Beads as a Sustainable Support for Industrially Relevant Lipases. ACS Sustainable Chemistry & Engineering. https://doi.org/10.1021/acssuschemeng.4c03708.

Recycling of Immobilised Enzymes

The ability to recycle immobilized enzymes is of paramount importance from an economic perspective. Enzymes are often expensive catalysts, and their reusability can significantly reduce operational costs in industrial processes. By immobilizing enzymes and enabling their recycling, companies can:

Decrease the overall enzyme consumption, leading to substantial cost savings
Improve process efficiency by maintaining catalytic activity over multiple cycles
Reduce waste generation and environmental impact
Enhance the economic viability of enzyme-based processes in various industries

Enzyme recycling is a critical advancement for improving the efficiency and cost-effectiveness of biocatalytic processes. The use of immobilized enzymes in technologies such as the RBR enables straightforward recovery and reuse of enzymes without significant loss of activity or selectivity. In Using SpinChem Rotating Bed Reactor Technology for Immobilized Enzymatic Reactions: A Case Study the authors demonstrates the successful application of RBR technology for the recycling of immobilized Novozym 435, highlighting its ability to maintain enzymatic enantioselectivity and catalytic efficiency across multiple cycles. By confining the immobilized enzyme within a controlled environment, RBR simplifies handling, reduces waste, and minimizes enzyme attrition caused by mechanical stress. The study effectively validates this approach by scaling up the process to 1 kg, achieving a ****39% isolated yield and 98.8% enantiomeric purity, reinforcing the RBR's viability for industrial applications.

Reference: Pithani, S., Karlsson, S., Entenis, H., & Öberg, C. T. (2019). Using SpinChem Rotating Bed Reactor Technology for Immobilized Enzymatic Reactions: A Case Study. Organic Process Research & Development, https://doi.org/10.1021/acs.oprd.9b00264.

Reaction Parameters and Applications

Several key reaction parameters play a crucial role in optimizing biocatalytic reactions:

Temperature: Affects enzyme activity, stability, and reaction rate. Each enzyme has an optimal temperature range.
pH: Influences enzyme structure and activity. Maintaining the correct pH is essential for optimal performance.
Substrate concentration: Impacts reaction kinetics and can lead to substrate inhibition at high levels.
Enzyme concentration: Determines the rate of reaction and overall process efficiency.
Reaction time: Affects product yield and may influence enzyme stability over extended periods.
Agitation speed: In systems like RBRs, affects mass transfer and enzyme-substrate interactions.
Solvent selection: Can impact enzyme stability and substrate solubility, especially in organic synthesis.

fine bubble aeration applied in a Rotating Bed Reactor

Bubble Size

Fine bubbles are pivotal in enhancing mass transfer in gas-liquid biocatalytic systems, particularly for oxygen-dependent reactions where solubility is a limiting factor. In this study, fine bubble aeration was applied in a Rotating Bed Reactor (RBR) to intensify a biocatalytic oxidation process. This approach resulted in a 12.9-fold increase in reaction rate, showcasing the substantial improvement in process efficiency. Additionally, the fine bubble aeration reduced oxygen consumption by an impressive 87%, highlighting its sustainability advantages. The fine bubbles significantly increased the oxygen transfer rate, achieving a volumetric mass transfer coefficient (kLa) approximately 2.7 times higher than conventional methods. These advancements demonstrate how fine bubble technology can effectively overcome oxygen limitations while promoting eco-friendly and scalable biotransformations.

Reference: Perçin, Z., Kursula, L., Löfgren, E., et al. (2024). Intensification of a Biocatalytic Oxidation Under Fine Bubble Aeration in a Rotating Bed Reactor. Biochemical Engineering Journal, https://doi.org/10.1016/j.bej.2024.109333.

Compartmentalisation

In complex chemical processes, the ability to separate and control different catalysts within a single reaction vessel is crucial for efficiency and selectivity. The SpinChem® Rotating Bed Reactor (RBR) exemplifies this capability by enabling the simultaneous use of multiple solid-phase materials, such as catalysts and adsorbents, within distinct compartments. This design allows for selective interactions tailored to specific reaction steps or purification needs.

A practical demonstration of this is the selective extraction of two dyes—Allura Red and Methylene Blue—onto different resins within the same RBR. In this setup, Allura Red was adsorbed onto Amberlite IRA900 Cl, while Methylene Blue was captured by Amberlite XAD1600N. Each adsorbent was placed in separate compartments of the RBR, which was operated at 800 rpm. This configuration facilitated the selective adsorption of each dye onto its respective resin, effectively separating them in a single process.

This approach not only simplifies the reaction setup but also enhances process efficiency by reducing the need for intermediate purification steps. By compartmentalizing different catalysts or adsorbents within the RBR, it becomes possible to conduct multistep reactions or simultaneous extractions in a streamlined manner, thereby improving overall productivity and selectivity in chemical manufacturing.

For a visual demonstration of this process, you can watch the following video: https://spinchem.com/application/simultaneous-extraction-of-two-dyes-selectively-onto-different-resins/

Dynamic Kinetic resolution

A notable example of applying compartmentalization for catalyst separation is the dynamic kinetic resolution (DKR) of secondary alcohols using Rotating Bed Reactors (RBRs). This approach utilizes a heterogeneous catalyst system, combining lipase (CAL-B) for enantioselective transesterification with a ruthenium-based racemization catalyst. The design of the RBR allowed for the physical separation of the chemical and enzymatic catalysts into distinct compartments, ensuring optimal performance while preventing undesired interactions between the catalysts.

This method achieved high conversions (>90%) and enantiomeric excess (up to >99%) across multiple reaction cycles (up to 5), demonstrating the scalability and recyclability of this system. The process produced 5.70 g of enantiopure (R)-ester, showcasing the efficiency of integrating dynamic resolution techniques with RBR technology. This highlights the significant advantage of RBRs in enabling selective reactions while maintaining process efficiency and sustainability.

Reference: de Almeida, L. A., Löfgren, E., de Fátima Milagre, C. D., & Milagre, H. M. S. (2024). Recyclable and Scalable Chemoenzymatic Dynamic Kinetic Resolution of Secondary Alcohols Using Rotating Bed Reactors for Catalyst Compartmentalization. Industrial & Engineering Chemistry Research, https://doi.org/10.1021/acs.iecr.3c01045.

Triphasic Reactor System

The development of innovative hybrid catalytic systems is driving a new era of efficiency and sustainability in chemical processes. An example is the design of a reactor for the one-step conversion of D-glucose to 5-hydroxymethylfurfural (HMF), which operates as a triphasic system. This reactor compartmentalizes the reaction into two chambers: one for the enzymatic conversion of glucose to fructose and another for the chemical conversion of fructose to HMF. By separating the aqueous and organic phases, this system achieves optimal conditions for each reaction while minimizing cross-contamination and maximizing product yield. Such creative designs highlight the potential of hybrid systems to revolutionize chemical manufacturing by improving process efficiency and selectivity.

Reference: Gimbernat, A., Heuson, E., Dumeignil, F., Delcroix, D., Girardon, J.-S., & Froidevaux, R. (2024). Reactor Development for a One-Step Hybrid Catalytic Conversion of D-Glucose to HMF. ChemCatChem. https://doi.org/10.1002/cctc.202300713.

Real-Time Monitoring

Knowing the parameters and optimizing reactor systems are critical components of designing efficient and sustainable chemical processes. However, achieving precision and real-time adaptability requires a deeper understanding—this is where monitoring comes into play. The integration of real-time monitoring techniques is revolutionizing how we approach reaction control, offering unprecedented accuracy and the ability to make immediate adjustments.

A prime example of this innovation is highlighted in a study that combines Rotating Bed Reactors (RBRs), Raman Spectroscopy, and green solvents to improve the sustainability of solid-phase peptide synthesis (SPPS). This work leverages process analytical tools (PAT) to monitor reactions as they occur, ensuring precise control over each step. By utilizing Raman spectroscopy, the researchers achieved real-time tracking of peptide resin reactions, allowing for timely interventions to optimize yields and reduce waste. The use of environmentally friendly solvents further underscores the importance of aligning monitoring with sustainable practices.

In this system, the SpinChem RBR plays a pivotal role. It provides a controlled environment for reactions to take place while enabling easy integration with PAT tools. This combination results in enhanced reaction efficiency, minimized resource consumption, and a significant reduction in time-to-completion. By uniting reactor design with advanced monitoring strategies, this approach offers a template for creating scalable, environmentally friendly processes in the pharmaceutical industry and beyond.

This story illustrates that while knowing parameters and reactor systems is vital, the ability to monitor reactions in real-time brings us closer to achieving the precision and sustainability needed in modern chemical synthesis.

Reference: Fournier, E., Vijeta, A., Babii, O., et al. (2024). Combining Real-Time Monitoring Using Raman Spectroscopy, Rotating-Bed Reactors, and Green Solvents to Improve Sustainability in Solid-Phase Peptide Synthesis. ACS Sustainable Chemistry & Engineering, https://doi.org/10.1021/acssuschemeng.4c01004.

Automation

Automation is revolutionizing production processes across industries, especially in fields requiring precision, scalability, and efficiency, such as pharmaceutical manufacturing and drug discovery. The integration of cyber-physical systems (CPS) into automated workcells exemplifies this transformation. One outstanding example is the development of an automated drug discovery workcell, which combines mechanical, computational, and digital components to streamline the drug discovery process.

cyber-physical workcell example in the pharmaceutical industry. — Cyber-physical workcell example, automation represents the future of efficient, reliable, and scalable production in the pharmaceutical industry.

This workcell integrates robotics, real-time monitoring, and advanced data analytics to execute repetitive and complex tasks with minimal human intervention. By automating processes such as liquid handling, mixing, and screening, it significantly reduces time-to-market and minimizes human error. The system is also designed for scalability, allowing manufacturers to quickly adapt to changing production demands or research priorities. Additionally, automation facilitates data-driven decision-making by continuously collecting and analyzing process data, improving consistency and quality control.

The adoption of such automated systems underscores the importance of embracing automation in real-world production environments. Not only does it enhance productivity, but it also fosters innovation by enabling researchers and engineers to focus on creative problem-solving rather than manual tasks. As seen in the cyber-physical workcell example, automation represents the future of efficient, reliable, and scalable production in the pharmaceutical industry.

Reference: ****Chng, C.-B., Koenig, K., Wong, P.-M., Wang, M., Wu, J., & Chui, C.-K. (2024). Towards a Pharmaceutical Cyber-Physical Systems Based Automated Drug Discovery Workcell. Acta Polytechnica Hungarica, Vol. 21, No. 9.

Scale-up

SpinChem® Rotating Bed Reactor (RBR) technology demonstrating scalability

The SpinChem® Rotating Bed Reactor (RBR) technology demonstrates exceptional scalability, allowing for seamless transition from laboratory to industrial-scale production. This scalability is achieved through the modular design of RBRs, which maintains consistent hydrodynamics and mass transfer characteristics across different sizes. As the reactor volume increases, the principles governing the RBR's operation remain constant, ensuring that the efficiency and performance observed in smaller-scale experiments are preserved in larger setups. This inherent scalability significantly reduces the time and resources typically required for process scale-up, making RBRs an ideal choice for industries seeking to rapidly move from product development to full-scale manufacturing while maintaining product quality and process efficiency.

The versatility of RBR technology is evident in its wide range of operational volumes. Laboratory-scale RBRs typically handle volumes from 0.5 to 20 liters, suitable for research and development. Pilot-scale units can accommodate 50 to 500 liters, bridging the gap between lab and industrial applications. For full-scale industrial processes, the SpinChem® Process RBR (ProRBR) can be designed for volumes ranging from 100 liters to several thousand cubic meters, catering to diverse manufacturing needs across various industries.

Next SpinChem Webinar

Mark your calendars for our next exciting webinar on 4 December 2024 at 14:30 CET, featuring the esteemed Prof. Dr.-Ing. Selin Kara as our guest speaker. Join us for an engaging session where we’ll delve into cutting-edge developments and insights in the field of biocatalysis and sustainable chemical processes. Don’t miss this opportunity to learn from one of the leading experts and explore innovative solutions shaping the future of the industry!

Bonus

If you're passionate about sustainable and innovative solutions in biocatalysis, enroll in the "Tailored Materials and Enzymes for Industrial Processes" MOOCs. These courses, developed as part of the EU project INTERfaces, provide a complete learning experience across three modules:

Basic Module: Perfect for beginners, this module introduces the foundational principles of enzyme production, protein engineering, and biocatalytic processes, featuring six units and 20 videos.
Advanced Module: For those seeking in-depth knowledge, this module covers advanced biocatalytic synthesis, process optimization, and industrial applications, building on the Basic Module.
Sustainability Module: Dive into specific, cutting-edge topics in biocatalysis and tailored materials, designed for professionals aiming to specialize in niche areas of this evolving field.

All three modules feature contributions from industry leaders like SpinChem, who share practical insights and real-world examples. Whether you're a student, researcher, or professional, these free and self-paced MOOCs provide the tools and knowledge to advance your career and contribute to the future of sustainable industrial processes. Enroll now and join a global community of innovators!

Any questions?

We'd love to discuss how our technology can be tailored to your unique applications. Whether you're considering a collaboration or have an upcoming project, our team is here to assist you.

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