"The global pharmaceutical industry, despite its growth, faces challenges in drug development, characterized by extensive timeframes and high costs. A significant bottleneck in this process is the labor-intensive and inefficient experimental synthesis in medicinal chemistry. The transition to automated methods offers a solution to these challenges, promising enhanced efficiency, scalability, and safety, while significantly reducing time and costs. This paper presents the development of an automated rotating bed reactor as part of an intelligent Cyber-Physical System-based automated drug discovery workcell. The automated rotating bed reactor is designed to be easily integrated as a component in the workcell, aiming to enable rapid adaptation to meet the specific needs of on-demand drug production. Experiments with the system show that it has the potential to enhance the yield of chemical reactions."
Keywords:
#automatedDrugDiscovery, #cyberPhysicalSystem, #pharmaceutical, #rotatingBedReactor, #drugDevelopment, #SpinChem
Highlights:
This paper explores the development of an intelligent, Cyber-Physical System (CPS)-based drug discovery workcell that includes a rotating bed reactor (RBR) designed to enhance efficiency in the pharmaceutical industry.
- The RBR provides benefits such as higher reaction yields, reduced time, and cost-effective production in small batches, which are essential for agile drug development.
- This approach has potential applications in on-demand production and could be adapted to meet varied drug production needs.
- SpinChem's RBR technology is mentioned for its unique advantage in handling solid-liquid reactions efficiently, contributing to advancements in automated synthesis.