“… Herein, we demonstrate the production of 1 kg of 4-acetoxy-3-methoxy-styrene in a 10 L reactor and present practical adjustments to the up- and downstream processing that warrant a straightforward process and high isolated yields. Additionally, an environmental assessment is conducted, … the total CO2 production of the process is studied, including contributions from energy use and the treatment of generated wastes. … Overall, the holistic assessment of the process, its optimization, scale-up, product isolation, and environmental analysis indicate the feasibility of multistep chemoenzymatic reactions to deliver high-volume, low-value chemicals from biorefineries.”
The image shows a graph with temperature and conversion data over time, accompanied by a series of five reactor photographs showing different stages of the process. The graph displays three lines: temperature (water jacket), decarboxylation, and acetylation, plotted against time over approximately 12 hours. Below the graph are five photographs of a reactor vessel showing the visual progression of the reaction from Decarboxylation start to Phase separation after quench
“The reaction cascade was conducted on a 120 mL lab scale using the SpinChem rotating bed reactor S2 in a 200 mL baffled glass reactor”
“Once the refined workup procedure was demonstrated on the lab scale, the reaction cascade was conducted on a 10 L scale to produce 1 kg AMS in a single batch.”
“Promising environmental metrics of the kilogram-scaled system, based on the E factor and the total CO2 released.”
