"In this work, we present the optimizations of the dynamic kinetic resolution of secondary alcohols using a heterogeneous lipase-vanadyl sulfate catalytic system in rotating bed reactors to compartmentalize both catalysts. The reactor design allowed the physical separation of the catalysts, overcoming mutual incompatibility. Furthermore, the commercial reactors filled with chemical and enzymatic catalysts provided a recyclable and scalable dynamic kinetic resolution (DKR) of secondary benzyl alcohols, achieving up to 5 cycles with high conversions (>90%) and enantiomeric excess (up to >99%) and producing 5.70 g of enantiopure (R)-ester."
Figure 1.
DKR reaction setup using the SpinChem MiniRBR prototype for CAL-B/VOSO4 compartmentalization
Figure 2.
Highlights:
The study reports on optimizing dynamic kinetic resolution (DKR) of secondary alcohols through a rotating bed reactor (RBR), with SpinChem's technology highlighted for compartmentalizing incompatible catalytic systems.
- The RBR design enables high recyclability and scalability in DKR processes.
- SpinChem RBRs allowed up to five consecutive high-yield cycles with minimal degradation, simplifying the recovery and reuse of catalysts and showcasing a scalable approach with potential industrial applications.