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Application 1023

Biocatalysis in rotating bed reactors - from screening to production

Enzyme screening is an important step in the development of a biocatalytic application. The behaviour of the biocatalyst is often hard to predict, meaning that different combinations of materials and reaction conditions need to be tested.

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This poster presents several esterification reactions and the screening efforts undertaken to develop them. The rotating bed reactors (RBRs) used constitute an excellent framework for biocatalytic reactions with immobilized enzymes. The RBR offers convenient handling of the solid phase by keeping it confined in the rotating bed behind stainless steel filters. Not only does this extend the catalyst lifetime, it also simplifies the separation allowing for fast screening and catalyst recovery.

Transesterification of racemate conversion with immobilized enzyme, Purolite CalB immo Plus lipase after repeated cycles over 28 days

Figure. Transesterification conversions of a racemic substrate by means of the immobilized enzyme 'Purolite CalB immo Plus lipase' in repeated cycles over 28 days.

 

SpinChem offers reactor models on all industrially relevant scales, meaning that the applications cover:

  • Discovery in the lab
  • Development in a pilot reactor
  • Production in a full plant

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Further reading:

Industries Pharmaceutical

Topics Biocatalysis, Reaction Screening

Products SpinChem® RBR S2, SpinChem® Vessel V2

Details

Conditions: This poster contains data from several reactions with immobilized enzymes performed at different conditions. The details of each reaction are displayed under each figure in the poster. This poster was presented at BioTrans2017 - the 13th international symposium on biocatalysis and biotransformations, in Budapest, Hungary, the 9th to 13th of July, 2017.